Drug interactions
Buspirone + Fexinidazole
Severity: Moderate
Buspirone and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites inhibit CYP3A4 and may raise buspirone levels. Excess sedation, dizziness and nausea are possible, and fexinidazole itself causes neuropsychiatric effects and QT prolongation.
What this interaction means in plain words
Buspirone and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole inhibits CYP3A4, reducing buspirone metabolism.
What to do
Consider starting with a reduced buspirone dose or holding it during the short fexinidazole course. Monitor for sedation, dizziness and neuropsychiatric symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Fexinidazole?
MediHelp rates the interaction as moderate. Buspirone and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites inhibit CYP3A4 and may raise buspirone levels. Excess sedation, dizziness and nausea are possible, and fexinidazole itself causes neuropsychiatric effects and QT prolongation.
How serious is the interaction between Buspirone and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider starting with a reduced buspirone dose or holding it during the short fexinidazole course. Monitor for sedation, dizziness and neuropsychiatric symptoms.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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