Drug interactions
Buspirone + Lsd
Severity: Moderate
Buspirone and Lsd: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
LSD is a potent serotonin receptor agonist, and combining it with buspirone may produce unpredictable serotonergic effects. Buspirone may blunt or alter the response to LSD, and a serotonin toxicity risk is theoretically possible.
What this interaction means in plain words
Buspirone and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Overlapping serotonin receptor activity, with buspirone acting at 5-HT1A and LSD acting at multiple 5-HT receptors; the interaction is poorly characterized.
What to do
Advise against recreational LSD use during buspirone therapy. If exposure occurs, monitor for agitation, hyperthermia, tremor and autonomic instability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Lsd?
MediHelp rates the interaction as moderate. Buspirone and Lsd can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. LSD is a potent serotonin receptor agonist, and combining it with buspirone may produce unpredictable serotonergic effects. Buspirone may blunt or alter the response to LSD, and a serotonin toxicity risk is theoretically possible.
How serious is the interaction between Buspirone and Lsd?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against recreational LSD use during buspirone therapy. If exposure occurs, monitor for agitation, hyperthermia, tremor and autonomic instability.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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