Drug interactions
Buspirone + Marijuana
Severity: Moderate
Buspirone and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can cause drowsiness, dizziness and impaired coordination, which may add to the effects of buspirone. Cannabidiol may also inhibit CYP3A4 and raise buspirone levels, although the clinical effect is not well characterized.
What this interaction means in plain words
Buspirone and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible CYP3A4 inhibition by cannabinoids.
What to do
Counsel patients about additive sedation and impaired driving. Monitor for dizziness and excessive drowsiness and adjust the buspirone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Marijuana?
MediHelp rates the interaction as moderate. Buspirone and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can cause drowsiness, dizziness and impaired coordination, which may add to the effects of buspirone. Cannabidiol may also inhibit CYP3A4 and raise buspirone levels, although the clinical effect is not well characterized.
How serious is the interaction between Buspirone and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive sedation and impaired driving. Monitor for dizziness and excessive drowsiness and adjust the buspirone dose if needed.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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