Drug interactions
Buspirone + Metoclopramide intranasal
Severity: Moderate
Buspirone and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide is a dopamine antagonist and buspirone also affects dopaminergic and serotonergic signaling, so the combination may increase extrapyramidal effects and rarely serotonin syndrome or neuroleptic malignant syndrome. Reports are limited.
What this interaction means in plain words
Buspirone and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive dopaminergic and serotonergic effects; the exact mechanism is not firmly established.
What to do
Monitor for extrapyramidal symptoms, restlessness and signs of serotonin toxicity, and use an alternative antiemetic if these appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Buspirone and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide is a dopamine antagonist and buspirone also affects dopaminergic and serotonergic signaling, so the combination may increase extrapyramidal effects and rarely serotonin syndrome or neuroleptic malignant syndrome. Reports are limited.
How serious is the interaction between Buspirone and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, restlessness and signs of serotonin toxicity, and use an alternative antiemetic if these appear.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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