Drug interactions
Buspirone + Midazolam intranasal
Severity: Moderate
Buspirone and Midazolam intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midazolam causes dose-related sedation and respiratory depression, and other CNS-active drugs can deepen or prolong its effects. Buspirone is less depressant than benzodiazepines but adds to drowsiness and impairment.
What this interaction means in plain words
Buspirone and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS depression.
What to do
Monitor sedation level and respiratory function after midazolam dosing, and do not give a repeat dose until the effect of the first has been assessed. Advise the patient not to drive or operate machinery after use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Buspirone
- Buspirone + Isocarboxazid Contraindicated
- Buspirone + Linezolid Contraindicated
- Buspirone + Phenelzine Contraindicated
- Buspirone + Procarbazine Contraindicated
- Buspirone + Selegiline Contraindicated
- Buspirone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Buspirone with Midazolam intranasal?
MediHelp rates the interaction as moderate. Buspirone and Midazolam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midazolam causes dose-related sedation and respiratory depression, and other CNS-active drugs can deepen or prolong its effects. Buspirone is less depressant than benzodiazepines but adds to drowsiness and impairment.
How serious is the interaction between Buspirone and Midazolam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory function after midazolam dosing, and do not give a repeat dose until the effect of the first has been assessed. Advise the patient not to drive or operate machinery after use.
What other medicines interact with Buspirone?
MediHelp also lists interactions of Buspirone with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Buspirone page.
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