Drug interactions
Butabarbital + Captopril-hydrochlorothiazide
Severity: Moderate
Butabarbital and Captopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates can cause additive blood pressure lowering and orthostatic hypotension with antihypertensive agents such as captopril and hydrochlorothiazide. The effect is usually modest but can cause dizziness and falls.
What this interaction means in plain words
Butabarbital and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from CNS depression and vasodilation combined with ACE inhibition and diuresis.
What to do
Monitor blood pressure and counsel patients about orthostatic symptoms, particularly at treatment initiation. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Butabarbital with Captopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Butabarbital and Captopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates can cause additive blood pressure lowering and orthostatic hypotension with antihypertensive agents such as captopril and hydrochlorothiazide. The effect is usually modest but can cause dizziness and falls.
How serious is the interaction between Butabarbital and Captopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel patients about orthostatic symptoms, particularly at treatment initiation. Reduce the antihypertensive dose if symptomatic hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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