Drug interactions
Butabarbital + Chloramphenicol
Severity: Moderate
Butabarbital and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloramphenicol can inhibit barbiturate metabolism, prolonging sedation. Barbiturates in turn induce enzymes and may lower chloramphenicol concentrations, risking treatment failure.
What this interaction means in plain words
Butabarbital and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chloramphenicol inhibits hepatic metabolism of barbiturates while barbiturates induce hepatic enzymes that clear chloramphenicol.
What to do
Monitor sedation and, if possible, chloramphenicol serum concentrations; adjust doses of both drugs accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Frequently asked questions
Can I take Butabarbital with Chloramphenicol?
MediHelp rates the interaction as moderate. Butabarbital and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol can inhibit barbiturate metabolism, prolonging sedation. Barbiturates in turn induce enzymes and may lower chloramphenicol concentrations, risking treatment failure.
How serious is the interaction between Butabarbital and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and, if possible, chloramphenicol serum concentrations; adjust doses of both drugs accordingly.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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