Drug interactions
Butabarbital + Chlorpheniramine
Severity: Moderate
Butabarbital and Chlorpheniramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and sedating antihistamines have additive CNS depressant effects, causing excessive drowsiness, impaired coordination and possible respiratory depression.
What this interaction means in plain words
Butabarbital and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and H1 antagonism.
What to do
Monitor sedation and respiratory function, and reduce doses if needed. Advise against alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpheniramine
Frequently asked questions
Can I take Butabarbital with Chlorpheniramine?
MediHelp rates the interaction as moderate. Butabarbital and Chlorpheniramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and sedating antihistamines have additive CNS depressant effects, causing excessive drowsiness, impaired coordination and possible respiratory depression.
How serious is the interaction between Butabarbital and Chlorpheniramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory function, and reduce doses if needed. Advise against alcohol and driving.
What other medicines interact with Chlorpheniramine?
MediHelp also lists interactions of Chlorpheniramine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Chlorpheniramine page.
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