Drug interactions
Butabarbital + Cilostazol
Severity: Moderate
Butabarbital and Cilostazol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are CYP3A4 inducers and may lower cilostazol concentrations. This could reduce the clinical benefit for claudication.
What this interaction means in plain words
Butabarbital and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by butabarbital increases cilostazol metabolism.
What to do
Monitor claudication symptoms and consider an alternative sedative if efficacy declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Frequently asked questions
Can I take Butabarbital with Cilostazol?
MediHelp rates the interaction as moderate. Butabarbital and Cilostazol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are CYP3A4 inducers and may lower cilostazol concentrations. This could reduce the clinical benefit for claudication.
How serious is the interaction between Butabarbital and Cilostazol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor claudication symptoms and consider an alternative sedative if efficacy declines.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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