Drug interactions
Butabarbital + Clopidogrel
Severity: Minor
Butabarbital and Clopidogrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP enzymes, possibly increasing conversion of clopidogrel to its active metabolite and enhancing antiplatelet effect. The clinical impact is uncertain.
What this interaction means in plain words
Butabarbital and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Enzyme induction by butabarbital may increase clopidogrel bioactivation.
What to do
No dose change is generally needed. Monitor for signs of bleeding with long-term combined use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clopidogrel
Frequently asked questions
Can I take Butabarbital with Clopidogrel?
MediHelp rates the interaction as minor. Butabarbital and Clopidogrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce CYP enzymes, possibly increasing conversion of clopidogrel to its active metabolite and enhancing antiplatelet effect. The clinical impact is uncertain.
How serious is the interaction between Butabarbital and Clopidogrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for signs of bleeding with long-term combined use.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
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