Drug interactions
Butabarbital + Cyclizine
Severity: Moderate
Butabarbital and Cyclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and sedating antihistamines both depress the CNS, so together they can cause excessive drowsiness, impaired coordination and, at higher doses, respiratory depression.
What this interaction means in plain words
Butabarbital and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and central H1 blockade.
What to do
Monitor sedation and breathing, advise against driving, and reduce the dose of one agent if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Butabarbital with Cyclizine?
MediHelp rates the interaction as moderate. Butabarbital and Cyclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and sedating antihistamines both depress the CNS, so together they can cause excessive drowsiness, impaired coordination and, at higher doses, respiratory depression.
How serious is the interaction between Butabarbital and Cyclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and breathing, advise against driving, and reduce the dose of one agent if oversedation occurs.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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