Drug interactions
Butabarbital + Dutasteride-tamsulosin
Severity: Minor
Butabarbital and Dutasteride-tamsulosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and could lower dutasteride and tamsulosin concentrations. Prolonged use may reduce therapeutic effect, though dutasteride's long half-life buffers short-term exposure.
What this interaction means in plain words
Butabarbital and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP3A4 increases metabolism of dutasteride and tamsulosin.
What to do
Monitor urinary symptom control if butabarbital is used long term. Adjust therapy if effect is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dutasteride-tamsulosin
Frequently asked questions
Can I take Butabarbital with Dutasteride-tamsulosin?
MediHelp rates the interaction as minor. Butabarbital and Dutasteride-tamsulosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce CYP3A4 and could lower dutasteride and tamsulosin concentrations. Prolonged use may reduce therapeutic effect, though dutasteride's long half-life buffers short-term exposure.
How serious is the interaction between Butabarbital and Dutasteride-tamsulosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urinary symptom control if butabarbital is used long term. Adjust therapy if effect is lost.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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