Drug interactions
Cobicistat + Dutasteride-tamsulosin
Severity: Major
Cobicistat and Dutasteride-tamsulosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a strong CYP3A inhibitor and CYP2D6 inhibitor that can substantially raise tamsulosin exposure. This increases the risk of symptomatic hypotension and syncope.
What this interaction means in plain words
Cobicistat and Dutasteride-tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cobicistat belongs to Miscellaneous; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Cobicistat inhibits CYP3A4 and CYP2D6, the main pathways of tamsulosin metabolism.
What to do
Avoid concurrent use and choose an alternative for BPH if possible. If coadministered, monitor blood pressure and counsel on orthostatic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Cobicistat with Dutasteride-tamsulosin?
MediHelp rates the interaction as major. Cobicistat and Dutasteride-tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat is a strong CYP3A inhibitor and CYP2D6 inhibitor that can substantially raise tamsulosin exposure. This increases the risk of symptomatic hypotension and syncope.
How serious is the interaction between Cobicistat and Dutasteride-tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose an alternative for BPH if possible. If coadministered, monitor blood pressure and counsel on orthostatic symptoms.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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