Drug interactions
Avanafil + Dutasteride-tamsulosin
Severity: Major
Avanafil and Dutasteride-tamsulosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both tamsulosin (an alpha-blocker) and avanafil (a PDE5 inhibitor) lower blood pressure through vasodilation. Taken together they can cause symptomatic hypotension, dizziness or fainting, particularly after the first dose or after a dose increase.
What this interaction means in plain words
Avanafil and Dutasteride-tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avanafil belongs to Genitourinary; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
Additive vasodilation from alpha-1 adrenergic blockade and PDE5 inhibition.
What to do
Ensure the patient is stable on the alpha-blocker before starting avanafil, and begin with the lowest avanafil dose. Counsel on orthostatic symptoms and avoid dose escalation if hypotension occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Frequently asked questions
Can I take Avanafil with Dutasteride-tamsulosin?
MediHelp rates the interaction as major. Avanafil and Dutasteride-tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both tamsulosin (an alpha-blocker) and avanafil (a PDE5 inhibitor) lower blood pressure through vasodilation. Taken together they can cause symptomatic hypotension, dizziness or fainting, particularly after the first dose or after a dose increase.
How serious is the interaction between Avanafil and Dutasteride-tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure the patient is stable on the alpha-blocker before starting avanafil, and begin with the lowest avanafil dose. Counsel on orthostatic symptoms and avoid dose escalation if hypotension occurs.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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