Drug interactions
Butabarbital + Felodipine
Severity: Moderate
Butabarbital and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can substantially lower felodipine concentrations. This may lead to loss of blood pressure or angina control.
What this interaction means in plain words
Butabarbital and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of CYP3A4 increases felodipine metabolism.
What to do
Monitor blood pressure and symptoms, and increase felodipine dose if needed. Consider an alternative antihypertensive for long-term barbiturate use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Butabarbital with Felodipine?
MediHelp rates the interaction as moderate. Butabarbital and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and can substantially lower felodipine concentrations. This may lead to loss of blood pressure or angina control.
How serious is the interaction between Butabarbital and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms, and increase felodipine dose if needed. Consider an alternative antihypertensive for long-term barbiturate use.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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