Drug interactions
Carbamazepine + Felodipine
Severity: Major
Carbamazepine and Felodipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine strongly induces CYP3A4 and substantially lowers felodipine exposure. This can lead to loss of blood pressure control.
What this interaction means in plain words
Carbamazepine and Felodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Felodipine belongs to Cardiovascular.
Why it happens
Carbamazepine induces CYP3A4, increasing felodipine first-pass metabolism.
What to do
Use an antihypertensive not dependent on CYP3A4 where possible. If combined, titrate felodipine to blood pressure and reassess when carbamazepine is changed or stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Clarithromycin + Felodipine Major
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Felodipine?
MediHelp rates the interaction as major. Carbamazepine and Felodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbamazepine strongly induces CYP3A4 and substantially lowers felodipine exposure. This can lead to loss of blood pressure control.
How serious is the interaction between Carbamazepine and Felodipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an antihypertensive not dependent on CYP3A4 where possible. If combined, titrate felodipine to blood pressure and reassess when carbamazepine is changed or stopped.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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