Drug interactions
Atazanavir + Felodipine
Severity: Major
Atazanavir and Felodipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir, especially when boosted with ritonavir or cobicistat, inhibits CYP3A4 and can raise felodipine concentrations markedly. This may cause hypotension, flushing, tachycardia and peripheral oedema.
What this interaction means in plain words
Atazanavir and Felodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Felodipine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated felodipine metabolism in gut and liver.
What to do
Use a low starting dose of felodipine and titrate cautiously, or choose a less CYP3A4-dependent antihypertensive. Monitor blood pressure and heart rate.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Carbamazepine + Felodipine Major
- Clarithromycin + Felodipine Major
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Felodipine?
MediHelp rates the interaction as major. Atazanavir and Felodipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir, especially when boosted with ritonavir or cobicistat, inhibits CYP3A4 and can raise felodipine concentrations markedly. This may cause hypotension, flushing, tachycardia and peripheral oedema.
How serious is the interaction between Atazanavir and Felodipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a low starting dose of felodipine and titrate cautiously, or choose a less CYP3A4-dependent antihypertensive. Monitor blood pressure and heart rate.
What other medicines interact with Felodipine?
MediHelp also lists interactions of Felodipine with, for example, Itraconazole, Aldesleukin, Amifostine. The full list is on the Felodipine page.
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