Drug interactions
Butabarbital + Loxapine
Severity: Moderate
Butabarbital and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and antipsychotics both depress the CNS, so combining them increases sedation, impaired psychomotor performance and hypotension. Barbiturates also induce hepatic enzymes and may lower loxapine exposure.
What this interaction means in plain words
Butabarbital and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; barbiturate induction of hepatic CYP enzymes may reduce loxapine levels.
What to do
Monitor sedation and blood pressure, and counsel the patient to avoid driving. Watch for reduced antipsychotic effect and adjust the loxapine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Butabarbital with Loxapine?
MediHelp rates the interaction as moderate. Butabarbital and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and antipsychotics both depress the CNS, so combining them increases sedation, impaired psychomotor performance and hypotension. Barbiturates also induce hepatic enzymes and may lower loxapine exposure.
How serious is the interaction between Butabarbital and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and blood pressure, and counsel the patient to avoid driving. Watch for reduced antipsychotic effect and adjust the loxapine dose if needed.
What other medicines interact with Loxapine?
MediHelp also lists interactions of Loxapine with, for example, Alfentanil, Alprazolam, Amisulpride. The full list is on the Loxapine page.
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