Drug interactions
Butabarbital + Nebivolol
Severity: Moderate
Butabarbital and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may lower plasma levels of beta-blockers that are extensively metabolized, potentially reducing blood pressure and heart rate control. Nebivolol is metabolized by CYP2D6 and glucuronidation, so the effect is likely modest.
What this interaction means in plain words
Butabarbital and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic drug-metabolizing enzymes increases the clearance of nebivolol.
What to do
Monitor heart rate and blood pressure when a barbiturate is started or stopped, and titrate the nebivolol dose to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Butabarbital with Nebivolol?
MediHelp rates the interaction as moderate. Butabarbital and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and may lower plasma levels of beta-blockers that are extensively metabolized, potentially reducing blood pressure and heart rate control. Nebivolol is metabolized by CYP2D6 and glucuronidation, so the effect is likely modest.
How serious is the interaction between Butabarbital and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when a barbiturate is started or stopped, and titrate the nebivolol dose to response.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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