Drug interactions
Butabarbital + Orphenadrin
Severity: Moderate
Butabarbital and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are potent CNS depressants and orphenadrine adds sedative and anticholinergic effects. The result may be excessive drowsiness, impaired coordination and, at higher doses, respiratory depression.
What this interaction means in plain words
Butabarbital and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and sedating antimuscarinic effects.
What to do
Use the lowest effective doses and monitor for oversedation. Counsel patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Butabarbital and Orphenadrin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Orphenadrin
Frequently asked questions
Can I take Butabarbital with Orphenadrin?
MediHelp rates the interaction as moderate. Butabarbital and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are potent CNS depressants and orphenadrine adds sedative and anticholinergic effects. The result may be excessive drowsiness, impaired coordination and, at higher doses, respiratory depression.
How serious is the interaction between Butabarbital and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for oversedation. Counsel patients to avoid driving and alcohol.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
