Drug interactions
Butabarbital + Prednisone
Severity: Moderate
Butabarbital and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can lower prednisolone concentrations, reducing steroid effect. This may lead to loss of disease control or adrenal insufficiency in dependent patients.
What this interaction means in plain words
Butabarbital and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of hepatic CYP3A4 by butabarbital increases prednisolone clearance.
What to do
Monitor clinical response and increase the prednisone dose if control is lost. Re-evaluate the dose when the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Butabarbital with Prednisone?
MediHelp rates the interaction as moderate. Butabarbital and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and can lower prednisolone concentrations, reducing steroid effect. This may lead to loss of disease control or adrenal insufficiency in dependent patients.
How serious is the interaction between Butabarbital and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the prednisone dose if control is lost. Re-evaluate the dose when the barbiturate is stopped.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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