Drug interactions
Butabarbital + Propafenone
Severity: Moderate
Butabarbital and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes including CYP3A4 and CYP1A2, which contribute to propafenone clearance. Propafenone levels may fall, reducing antiarrhythmic efficacy.
What this interaction means in plain words
Butabarbital and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butabarbital induces CYP3A4 and CYP1A2, increasing propafenone metabolism.
What to do
Monitor for arrhythmia recurrence and ECG response, and consider propafenone dose adjustment. Re-evaluate the dose if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Butabarbital with Propafenone?
MediHelp rates the interaction as moderate. Butabarbital and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes including CYP3A4 and CYP1A2, which contribute to propafenone clearance. Propafenone levels may fall, reducing antiarrhythmic efficacy.
How serious is the interaction between Butabarbital and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for arrhythmia recurrence and ECG response, and consider propafenone dose adjustment. Re-evaluate the dose if the barbiturate is stopped.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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