Drug interactions
Butabarbital + Rimegepant
Severity: Major
Butabarbital and Rimegepant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can markedly lower rimegepant concentrations. This may cause therapeutic failure for migraine.
What this interaction means in plain words
Butabarbital and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 by butabarbital increases rimegepant metabolism.
What to do
Avoid concomitant use of rimegepant with butabarbital. Choose an alternative acute migraine therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rimegepant
- Amobarbital + Rimegepant Major
- Atazanavir + Rimegepant Major
- Butalbital + Rimegepant Major
- Clarithromycin + Rimegepant Major
- Cobicistat + Rimegepant Major
- Conivaptan + Rimegepant Major
Frequently asked questions
Can I take Butabarbital with Rimegepant?
MediHelp rates the interaction as major. Butabarbital and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Barbiturates induce CYP3A4 and can markedly lower rimegepant concentrations. This may cause therapeutic failure for migraine.
How serious is the interaction between Butabarbital and Rimegepant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use of rimegepant with butabarbital. Choose an alternative acute migraine therapy.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butalbital. The full list is on the Rimegepant page.
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