Drug interactions
Atazanavir + Rimegepant
Severity: Major
Atazanavir and Rimegepant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and can substantially raise rimegepant exposure. This may increase adverse effects of rimegepant.
What this interaction means in plain words
Atazanavir and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Rimegepant belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of rimegepant.
What to do
Avoid concomitant use. Choose another acute migraine treatment while the patient takes atazanavir.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rimegepant
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Rimegepant?
MediHelp rates the interaction as major. Atazanavir and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and can substantially raise rimegepant exposure. This may increase adverse effects of rimegepant.
How serious is the interaction between Atazanavir and Rimegepant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use. Choose another acute migraine treatment while the patient takes atazanavir.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Butabarbital, Butalbital. The full list is on the Rimegepant page.
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