Drug interactions
Butalbital + Rimegepant
Severity: Major
Butalbital and Rimegepant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that can induce CYP3A4 and reduce rimegepant exposure. Rimegepant may become ineffective for acute migraine.
What this interaction means in plain words
Butalbital and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Induction of CYP3A4 by butalbital increases rimegepant metabolism.
What to do
Avoid combining the two. Use a different acute migraine agent when butalbital-containing products are needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rimegepant
Frequently asked questions
Can I take Butalbital with Rimegepant?
MediHelp rates the interaction as major. Butalbital and Rimegepant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Butalbital is a barbiturate that can induce CYP3A4 and reduce rimegepant exposure. Rimegepant may become ineffective for acute migraine.
How serious is the interaction between Butalbital and Rimegepant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining the two. Use a different acute migraine agent when butalbital-containing products are needed.
What other medicines interact with Rimegepant?
MediHelp also lists interactions of Rimegepant with, for example, Amobarbital, Atazanavir, Butabarbital. The full list is on the Rimegepant page.
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