Drug interactions
Butabarbital + Terbinafine
Severity: Moderate
Butabarbital and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes and may increase terbinafine clearance. Reduced terbinafine concentrations could lessen antifungal efficacy, particularly in nail infections that need sustained exposure.
What this interaction means in plain words
Butabarbital and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butabarbital induces CYP enzymes, accelerating terbinafine metabolism.
What to do
Monitor clinical response to terbinafine and consider a longer course or alternative if response is poor. Avoid the combination in long-term therapy if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Frequently asked questions
Can I take Butabarbital with Terbinafine?
MediHelp rates the interaction as moderate. Butabarbital and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes and may increase terbinafine clearance. Reduced terbinafine concentrations could lessen antifungal efficacy, particularly in nail infections that need sustained exposure.
How serious is the interaction between Butabarbital and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to terbinafine and consider a longer course or alternative if response is poor. Avoid the combination in long-term therapy if possible.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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