Drug interactions
Butabarbital + Tinidazole
Severity: Moderate
Butabarbital and Tinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates are enzyme inducers and may lower tinidazole concentrations, potentially reducing its antimicrobial effect. The effect is predicted from the related nitroimidazole metronidazole and from induction principles rather than extensively studied.
What this interaction means in plain words
Butabarbital and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate induction of hepatic CYP enzymes increases tinidazole metabolism.
What to do
Monitor clinical response to tinidazole, particularly in serious infections. Consider a longer course or alternative therapy if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Frequently asked questions
Can I take Butabarbital with Tinidazole?
MediHelp rates the interaction as moderate. Butabarbital and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates are enzyme inducers and may lower tinidazole concentrations, potentially reducing its antimicrobial effect. The effect is predicted from the related nitroimidazole metronidazole and from induction principles rather than extensively studied.
How serious is the interaction between Butabarbital and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to tinidazole, particularly in serious infections. Consider a longer course or alternative therapy if response is inadequate.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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