Drug interactions
Nilotinib + Tinidazole
Severity: Major
Nilotinib and Tinidazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and nilotinib also inhibits CYP3A4, which may raise tinidazole exposure. Tinidazole carries a labeled QT warning, so combined use may increase the risk of torsades de pointes, especially with electrolyte disturbances.
What this interaction means in plain words
Nilotinib and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Nilotinib belongs to Oncology; Tinidazole belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, with possible CYP3A4 inhibition by nilotinib raising tinidazole levels.
What to do
Avoid the combination where possible; if unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Ritonavir + Tinidazole Major
- Amiodarone + Tinidazole Moderate
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Nilotinib with Tinidazole?
MediHelp rates the interaction as major. Nilotinib and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and nilotinib also inhibits CYP3A4, which may raise tinidazole exposure. Tinidazole carries a labeled QT warning, so combined use may increase the risk of torsades de pointes, especially with electrolyte disturbances.
How serious is the interaction between Nilotinib and Tinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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