Drug interactions
Butabarbital + Tolbutamide
Severity: Minor
Butabarbital and Tolbutamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes, including CYP2C9, which may speed the clearance of tolbutamide. This could reduce its glucose-lowering effect.
What this interaction means in plain words
Butabarbital and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate induction of CYP2C9 increases tolbutamide metabolism.
What to do
Monitor blood glucose when butabarbital is started or stopped. Adjust the tolbutamide dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Butabarbital with Tolbutamide?
MediHelp rates the interaction as minor. Butabarbital and Tolbutamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Barbiturates induce hepatic enzymes, including CYP2C9, which may speed the clearance of tolbutamide. This could reduce its glucose-lowering effect.
How serious is the interaction between Butabarbital and Tolbutamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when butabarbital is started or stopped. Adjust the tolbutamide dose if control changes.
What other medicines interact with Tolbutamide?
MediHelp also lists interactions of Tolbutamide with, for example, Glyburide-metformin, Insulin degludec-liraglutide, Aceclofenac. The full list is on the Tolbutamide page.
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