Drug interactions
Butabarbital + Verapamil
Severity: Moderate
Butabarbital and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can lower verapamil concentrations, reducing blood pressure or rate control. Additive sedation is not typical for verapamil but efficacy may be lost.
What this interaction means in plain words
Butabarbital and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butabarbital induces CYP3A4, increasing verapamil first-pass and systemic metabolism.
What to do
Monitor heart rate and blood pressure and increase the verapamil dose if the response diminishes; reassess dose if the barbiturate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Butabarbital with Verapamil?
MediHelp rates the interaction as moderate. Butabarbital and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and can lower verapamil concentrations, reducing blood pressure or rate control. Additive sedation is not typical for verapamil but efficacy may be lost.
How serious is the interaction between Butabarbital and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and increase the verapamil dose if the response diminishes; reassess dose if the barbiturate is stopped.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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