Drug interactions
Butabarbital + Vinblastine
Severity: Moderate
Butabarbital and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and can increase vinblastine clearance. This may reduce vinblastine exposure and efficacy.
What this interaction means in plain words
Butabarbital and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated CYP3A4 induction increases vinblastine metabolism.
What to do
Avoid prolonged barbiturate use where alternatives exist. Monitor tumor response to vinblastine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Butabarbital with Vinblastine?
MediHelp rates the interaction as moderate. Butabarbital and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and can increase vinblastine clearance. This may reduce vinblastine exposure and efficacy.
How serious is the interaction between Butabarbital and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged barbiturate use where alternatives exist. Monitor tumor response to vinblastine.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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