Drug interactions
Apalutamide + Vinblastine
Severity: Major
Apalutamide and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce vinblastine exposure through enzyme induction. Reduced cytotoxic exposure could compromise anticancer efficacy.
What this interaction means in plain words
Apalutamide and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Apalutamide belongs to Endocrine; Vinblastine belongs to Oncology.
Why it happens
Apalutamide induces CYP3A4, increasing the metabolism of vinblastine, a CYP3A4 substrate.
What to do
Avoid the combination or choose an alternative where feasible. If used together, monitor for reduced tumor response and for changes in toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Apalutamide with Vinblastine?
MediHelp rates the interaction as major. Apalutamide and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Apalutamide may reduce vinblastine exposure through enzyme induction. Reduced cytotoxic exposure could compromise anticancer efficacy.
How serious is the interaction between Apalutamide and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination or choose an alternative where feasible. If used together, monitor for reduced tumor response and for changes in toxicity.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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