Drug interactions
Atazanavir + Vinblastine
Severity: Major
Atazanavir and Vinblastine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir inhibits CYP3A4 and may increase vinblastine exposure. This raises the risk of severe myelosuppression, neurotoxicity and constipation or ileus.
What this interaction means in plain words
Atazanavir and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Vinblastine belongs to Oncology.
Why it happens
CYP3A4 inhibition by atazanavir (with or without ritonavir or cobicistat boosting) reduces vinblastine clearance.
What to do
Prefer an antiretroviral regimen without a CYP3A4 inhibitor during vinblastine therapy. If unavoidable, monitor blood counts and neurologic and GI toxicity and reduce vinblastine as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Vinblastine
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Vinblastine?
MediHelp rates the interaction as major. Atazanavir and Vinblastine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir inhibits CYP3A4 and may increase vinblastine exposure. This raises the risk of severe myelosuppression, neurotoxicity and constipation or ileus.
How serious is the interaction between Atazanavir and Vinblastine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiretroviral regimen without a CYP3A4 inhibitor during vinblastine therapy. If unavoidable, monitor blood counts and neurologic and GI toxicity and reduce vinblastine as needed.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Chloramphenicol. The full list is on the Vinblastine page.
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