Drug interactions
Butabarbital + Ziprasidone
Severity: Moderate
Butabarbital and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates and ziprasidone both depress the CNS, increasing drowsiness, impaired coordination and respiratory depression. Butabarbital may also lower ziprasidone exposure through enzyme induction, though this is a minor contributor.
What this interaction means in plain words
Butabarbital and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression; barbiturate induction of CYP3A4 may modestly lower ziprasidone levels.
What to do
Use the lowest effective doses and counsel on avoiding driving and alcohol. Monitor sedation and psychiatric response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Butabarbital with Ziprasidone?
MediHelp rates the interaction as moderate. Butabarbital and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates and ziprasidone both depress the CNS, increasing drowsiness, impaired coordination and respiratory depression. Butabarbital may also lower ziprasidone exposure through enzyme induction, though this is a minor contributor.
How serious is the interaction between Butabarbital and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel on avoiding driving and alcohol. Monitor sedation and psychiatric response.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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