Drug interactions
Butalbital + Cariprazine
Severity: Moderate
Butalbital and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that adds to sedation and impaired alertness with cariprazine. Enzyme induction by barbiturates may also lower cariprazine levels, although the effect from intermittent butalbital use is likely small.
What this interaction means in plain words
Butalbital and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with possible weak CYP3A4 induction by butalbital.
What to do
Limit butalbital use to occasional doses and monitor for oversedation. Watch for reduced psychiatric response if butalbital is taken frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cariprazine
Frequently asked questions
Can I take Butalbital with Cariprazine?
MediHelp rates the interaction as moderate. Butalbital and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that adds to sedation and impaired alertness with cariprazine. Enzyme induction by barbiturates may also lower cariprazine levels, although the effect from intermittent butalbital use is likely small.
How serious is the interaction between Butalbital and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit butalbital use to occasional doses and monitor for oversedation. Watch for reduced psychiatric response if butalbital is taken frequently.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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