Drug interactions
Butalbital + Celecoxib
Severity: Minor
Butalbital and Celecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate and may induce CYP2C9, potentially reducing celecoxib exposure. Clinical relevance is probably small with intermittent use.
What this interaction means in plain words
Butalbital and Celecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated induction of CYP2C9 raises celecoxib clearance.
What to do
Monitor for diminished celecoxib response in patients using butalbital regularly. No dose change is needed for occasional use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Butalbital with Celecoxib?
MediHelp rates the interaction as minor. Butalbital and Celecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate and may induce CYP2C9, potentially reducing celecoxib exposure. Clinical relevance is probably small with intermittent use.
How serious is the interaction between Butalbital and Celecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for diminished celecoxib response in patients using butalbital regularly. No dose change is needed for occasional use.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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