Drug interactions
Butalbital + Chlorzoxazone
Severity: Moderate
Butalbital and Chlorzoxazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so taking them together can cause deeper drowsiness, dizziness and impaired psychomotor performance. Barbiturate-containing analgesic products can add to the sedation of a muscle relaxant, which raises the risk of falls and accidents.
What this interaction means in plain words
Butalbital and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, with butalbital enhancing GABA-A receptor activity and chlorzoxazone acting as a centrally acting muscle relaxant.
What to do
Start with the lowest effective doses and warn the patient about driving and operating machinery. Reassess the need for both drugs if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Frequently asked questions
Can I take Butalbital with Chlorzoxazone?
MediHelp rates the interaction as moderate. Butalbital and Chlorzoxazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so taking them together can cause deeper drowsiness, dizziness and impaired psychomotor performance. Barbiturate-containing analgesic products can add to the sedation of a muscle relaxant, which raises the risk of falls and accidents.
How serious is the interaction between Butalbital and Chlorzoxazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and warn the patient about driving and operating machinery. Reassess the need for both drugs if excessive sedation occurs.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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