Drug interactions
Butalbital + Imatinib
Severity: Moderate
Butalbital and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that induces CYP3A4 and may lower imatinib concentrations. Intermittent use probably has limited effect, but regular use could reduce efficacy.
What this interaction means in plain words
Butalbital and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butalbital induces CYP3A4, increasing imatinib clearance.
What to do
Avoid regular use and choose a different headache therapy. Monitor the imatinib response if it is used frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Butalbital with Imatinib?
MediHelp rates the interaction as moderate. Butalbital and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that induces CYP3A4 and may lower imatinib concentrations. Intermittent use probably has limited effect, but regular use could reduce efficacy.
How serious is the interaction between Butalbital and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use and choose a different headache therapy. Monitor the imatinib response if it is used frequently.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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