Drug interactions
Butalbital + Levetiracetam
Severity: Moderate
Butalbital and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate with sedative effects, and levetiracetam adds somnolence and dizziness. Combined use may increase drowsiness and impair coordination.
What this interaction means in plain words
Butalbital and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Monitor for excessive sedation and counsel on driving and alcohol avoidance. Limit butalbital use to the lowest effective amount.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levetiracetam
Frequently asked questions
Can I take Butalbital with Levetiracetam?
MediHelp rates the interaction as moderate. Butalbital and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate with sedative effects, and levetiracetam adds somnolence and dizziness. Combined use may increase drowsiness and impair coordination.
How serious is the interaction between Butalbital and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and counsel on driving and alcohol avoidance. Limit butalbital use to the lowest effective amount.
What other medicines interact with Levetiracetam?
MediHelp also lists interactions of Levetiracetam with, for example, Oliceridine, Opium tincture, Sodium oxybate. The full list is on the Levetiracetam page.
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