Drug interactions
Butalbital + Levothyroxine
Severity: Minor
Butalbital and Levothyroxine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce hepatic enzymes and speed levothyroxine clearance. The effect is most relevant with regular, prolonged use and could cause under-replacement.
What this interaction means in plain words
Butalbital and Levothyroxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated enzyme induction increases hepatic metabolism of levothyroxine.
What to do
Check TSH if butalbital is used regularly and adjust the levothyroxine dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Levothyroxine
Frequently asked questions
Can I take Butalbital with Levothyroxine?
MediHelp rates the interaction as minor. Butalbital and Levothyroxine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that may induce hepatic enzymes and speed levothyroxine clearance. The effect is most relevant with regular, prolonged use and could cause under-replacement.
How serious is the interaction between Butalbital and Levothyroxine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH if butalbital is used regularly and adjust the levothyroxine dose as needed.
What other medicines interact with Levothyroxine?
MediHelp also lists interactions of Levothyroxine with, for example, Cholestyramine, Sodium iodide i-131, Tiratricol. The full list is on the Levothyroxine page.
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