Drug interactions
Butalbital + Orphenadrin
Severity: Moderate
Butalbital and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a sedating barbiturate and orphenadrine adds CNS depression and anticholinergic effects. Drowsiness, dizziness and impaired psychomotor function may be increased.
What this interaction means in plain words
Butalbital and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via GABA-A potentiation and antimuscarinic sedation.
What to do
Monitor for oversedation and reduce doses if needed. Advise patients not to drive or drink alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Frequently asked questions
Can I take Butalbital with Orphenadrin?
MediHelp rates the interaction as moderate. Butalbital and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a sedating barbiturate and orphenadrine adds CNS depression and anticholinergic effects. Drowsiness, dizziness and impaired psychomotor function may be increased.
How serious is the interaction between Butalbital and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and reduce doses if needed. Advise patients not to drive or drink alcohol.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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