Drug interactions
Butalbital + Paclitaxel
Severity: Minor
Butalbital and Paclitaxel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and slightly lower paclitaxel levels. Intermittent use is unlikely to matter much clinically.
What this interaction means in plain words
Butalbital and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Barbiturate-mediated induction of CYP3A4 increases paclitaxel metabolism.
What to do
Limit frequent butalbital use and monitor response to paclitaxel.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Frequently asked questions
Can I take Butalbital with Paclitaxel?
MediHelp rates the interaction as minor. Butalbital and Paclitaxel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Butalbital is a barbiturate that may induce CYP3A4 and slightly lower paclitaxel levels. Intermittent use is unlikely to matter much clinically.
How serious is the interaction between Butalbital and Paclitaxel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit frequent butalbital use and monitor response to paclitaxel.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporin. The full list is on the Paclitaxel page.
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