Drug interactions
Butalbital + Propafenone
Severity: Moderate
Butalbital and Propafenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce hepatic enzymes involved in propafenone metabolism, potentially lowering propafenone levels and reducing arrhythmia control. Clinical data are limited and effect depends on duration of use.
What this interaction means in plain words
Butalbital and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Butalbital may induce CYP3A4 and CYP1A2, increasing propafenone clearance.
What to do
Monitor for loss of rhythm control and ECG changes with regular butalbital use. Adjust propafenone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Butalbital with Propafenone?
MediHelp rates the interaction as moderate. Butalbital and Propafenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that may induce hepatic enzymes involved in propafenone metabolism, potentially lowering propafenone levels and reducing arrhythmia control. Clinical data are limited and effect depends on duration of use.
How serious is the interaction between Butalbital and Propafenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of rhythm control and ECG changes with regular butalbital use. Adjust propafenone dose if needed.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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