Drug interactions
Butalbital + Quetiapine
Severity: Moderate
Butalbital and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that may induce CYP3A4 and reduce quetiapine levels, though the effect of intermittent low doses is smaller than with chronic phenobarbital. Both drugs also cause sedation.
What this interaction means in plain words
Butalbital and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-related CYP3A4 induction and additive CNS depression.
What to do
Monitor for reduced quetiapine response with regular butalbital use and for excess drowsiness. Adjust the quetiapine dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Butalbital with Quetiapine?
MediHelp rates the interaction as moderate. Butalbital and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that may induce CYP3A4 and reduce quetiapine levels, though the effect of intermittent low doses is smaller than with chronic phenobarbital. Both drugs also cause sedation.
How serious is the interaction between Butalbital and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced quetiapine response with regular butalbital use and for excess drowsiness. Adjust the quetiapine dose according to clinical response.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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