Drug interactions
Butalbital + Tranylcypromine
Severity: Minor
Butalbital and Tranylcypromine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may prolong and intensify the effect of barbiturates such as butalbital, producing excess sedation. The evidence is largely theoretical, but combination products also contain other agents.
What this interaction means in plain words
Butalbital and Tranylcypromine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduced barbiturate metabolism and additive CNS depression.
What to do
Monitor for oversedation and use the lowest effective butalbital dose. Check the other ingredients in combination products for MAOI interactions.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Butalbital and Tranylcypromine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Butalbital with Tranylcypromine?
MediHelp rates the interaction as minor. Butalbital and Tranylcypromine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. MAO inhibitors may prolong and intensify the effect of barbiturates such as butalbital, producing excess sedation. The evidence is largely theoretical, but combination products also contain other agents.
How serious is the interaction between Butalbital and Tranylcypromine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and use the lowest effective butalbital dose. Check the other ingredients in combination products for MAOI interactions.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
