Drug interactions
Butorphanol + Cariprazine
Severity: Moderate
Butorphanol and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine may cause somnolence and, combined with an opioid, sedation and dizziness can be greater. This may impair driving and increase falls.
What this interaction means in plain words
Butorphanol and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Cariprazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid agonism and antipsychotic receptor activity.
What to do
Monitor sedation and orthostatic symptoms when starting or titrating either drug. Reduce the opioid dose if excessive drowsiness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Butorphanol with Cariprazine?
MediHelp rates the interaction as moderate. Butorphanol and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine may cause somnolence and, combined with an opioid, sedation and dizziness can be greater. This may impair driving and increase falls.
How serious is the interaction between Butorphanol and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic symptoms when starting or titrating either drug. Reduce the opioid dose if excessive drowsiness occurs.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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