Drug interactions
Butorphanol + Cimetidine
Severity: Minor
Butorphanol and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may increase butorphanol exposure, raising the possibility of added sedation and respiratory depression. Supporting data are limited.
What this interaction means in plain words
Butorphanol and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Butorphanol belongs to Musculoskeletal; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine may inhibit hepatic CYP3A4 metabolism of butorphanol; the mechanism is not firmly established.
What to do
Monitor sedation and respiratory rate, and lower the butorphanol dose if excessive effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Cimetidine?
MediHelp rates the interaction as minor. Butorphanol and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may increase butorphanol exposure, raising the possibility of added sedation and respiratory depression. Supporting data are limited.
How serious is the interaction between Butorphanol and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory rate, and lower the butorphanol dose if excessive effects appear.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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