Drug interactions
Butorphanol + Lemborexant
Severity: Moderate
Butorphanol and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS, so combining them may cause additive sedation and impaired next-day function. Respiratory depression is also a concern with opioids plus other sedatives.
What this interaction means in plain words
Butorphanol and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Lemborexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid activity and orexin receptor antagonism.
What to do
Use the lowest effective doses and monitor for sedation and impaired alertness. Reduce the lemborexant dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Lemborexant
Frequently asked questions
Can I take Butorphanol with Lemborexant?
MediHelp rates the interaction as moderate. Butorphanol and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS, so combining them may cause additive sedation and impaired next-day function. Respiratory depression is also a concern with opioids plus other sedatives.
How serious is the interaction between Butorphanol and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and impaired alertness. Reduce the lemborexant dose if excessive sedation occurs.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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