Drug interactions
Butorphanol + Loxapine
Severity: Moderate
Butorphanol and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so using them together can cause excessive drowsiness, impaired psychomotor performance and reduced respiratory drive. Risk is greater in older or debilitated patients.
What this interaction means in plain words
Butorphanol and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid activity plus antipsychotic antihistaminic and anticholinergic sedative effects.
What to do
Start with reduced doses of one or both agents and monitor sedation and respiratory status. Counsel against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Butorphanol with Loxapine?
MediHelp rates the interaction as moderate. Butorphanol and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so using them together can cause excessive drowsiness, impaired psychomotor performance and reduced respiratory drive. Risk is greater in older or debilitated patients.
How serious is the interaction between Butorphanol and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses of one or both agents and monitor sedation and respiratory status. Counsel against driving and alcohol use.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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