Drug interactions
Butorphanol + Metaxalone
Severity: Moderate
Butorphanol and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaxalone is a sedating skeletal muscle relaxant, and combining it with an opioid increases drowsiness, dizziness and psychomotor impairment. Respiratory depression is possible at higher doses.
What this interaction means in plain words
Butorphanol and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid action and the central effects of metaxalone.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Metaxalone
Frequently asked questions
Can I take Butorphanol with Metaxalone?
MediHelp rates the interaction as moderate. Butorphanol and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metaxalone is a sedating skeletal muscle relaxant, and combining it with an opioid increases drowsiness, dizziness and psychomotor impairment. Respiratory depression is possible at higher doses.
How serious is the interaction between Butorphanol and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Advise against driving and alcohol.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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